12/14/16 news article
Gala of Hope Foundation donation will help shape the future of pediatric cancer research
The Gala of Hope Foundation donated $198,870 to Dayton Children’s Hospital, providing for the next step in furthering pediatric cancer research in the Dayton region. Bob and Barbara Mills, Gala of Hope Foundation co-founders, presented the giant check to pediatric neurosurgeon Robert Lober, MD, PhD, in the Mills Family Lounge at Dayton Children’s on Wednesday, December 14, 2016.
“There is nothing closer to my heart than finding new ways to fight cancer, and ultimately end it, before any child has to go through what my granddaughter did,” says Bob Mills. His granddaughter, Ally, successfully battled cancer at Dayton Children’s. “I believe the research going on right now, right here in our community could do that.”
Through Dayton Children’s affiliation with the Wright State University & Premier Health Neuroscience Institute, Dr. Lober is researching brain tumors in children and using high-level imaging to find out what is going on inside them. This donation will be used to create a research tissue bank, purchasing specialized freezers that store, code and organize the tissue samples and hiring a research-level scientist to coordinate the work.
We may think of tumors as just blobs of tissue, but they are actually our bodies’ own cells turned into renegades, bent on destruction. Just like our healthy cells, they have their own metabolism. They need energy to grow and they also give off energy. To understand that process, at its molecular level, is Dr. Lober’s goal.
To begin the research, Dr. Lober started with test samples he brought with him when he came from Stanford University. “What we are doing is setting up a tissue study pipeline,” says Dr. Lober. “We created an imaging infrastructure to bring data to a cloud-based server for our researchers. We are using the highest level of technology you can find anywhere to study the metabolism of tumors.”
This initiative is bridging the gap between pediatric neurosurgeons, pediatric oncologists, physicists, mathematicians, radiologists, pathologists, biochemists and many others within Dayton Children’s and the Neuroscience Institute. “The amazing thing is we have come further in one year with this collaboration than you could at a larger research institution in many years. It’s all about being nimble and being able to move quickly. We are demonstrating the capabilities that we have by leveraging our smallness.”
Robert E.W. Fyffe, PhD, vice president for research and dean of the graduate school at Wright State University, says the Neuroscience Institute brings strong interdisciplinary teams together to speed the transfer of research discoveries from bench to bedside. “We know we have some of the best minds right here in Dayton, and they are eager to dive into projects like this,” says Fyffe. “This research will make a difference and change lives.”
Dr. Lober is working closely with Debra Mayes, PhD, and Tom Brown, PhD, at the Neuroscience Institute and is now starting a process allowing other institutions to donate tissue. Each tumor review will add to the pool of knowledge, down to the molecular level, of not only what the tumor cells are, but how they breathe, eat and reproduce. The use of the 3T MRI at Dayton Children’s, with twice the quality and clarity of most current MRI scanners, is helping him in this research.
“This process will be an incredibly powerful tool for cancer research,” says Dr. Lober. “You can’t see a gene on an MRI, but you can see how a tumor uses and gives off energy. We are seeing unique patterns of this type of behavior with different tumor types based on their gene expression profiles. Eventually we should be able to reverse engineer this process. One day we might be able to take an MRI of a child’s brain and know, without a biopsy, without any invasive procedures, what kind of cancer it is and how to best defeat it.”
“We could not do any of the work we do without the generous support of the community,” says Deborah Feldman, president and CEO of Dayton Children’s. “This is our third grant from the Gala of Hope Foundation and we thank Bob and Barbara Mills for continuing to believe in and support our mission to care for each child as if they were our own child.”
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