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Richard Strait, MD

expertise

emergency medicine

bio

Richard Strait, MD is the associate chief of the emergency department at Dayton Children's and medical director for the south campus emergency department.

education and training

  • medical school: University of Cincinnati College of Medicine
  • internship: Cincinnati Children's Hospital Medical Center
  • residency: Cincinnati Children's Hospital Medical Center - pediatrics
  • fellowship: Cincinnati Children's Hospital Medical Center - pediatric emergency medicine
  • board certification: pediatrics and pediatric emergency medicine

publications and presentations

peer-reviewed publications: (h-index 23, total of 2919 citations as of February 19, 2020 including reviews and invited papers – researchgate)

  • Strait RT, Siegel RM and Shapiro RA. Humeral Fractures Without Obvious Etiologies in Children Under Three Years of Age: When is it Abuse?. Pediatrics 1995;96:667-671. PMID 7567328
  • Strait RT, Ruddy RM, Friedland R, Duncan KM and Wilmott RW. A pilot study on the predictive value of plasma TNFa and IL1b for S. Pneumoniae bacteremia in febrile children. Academic Emergency Medicine, Acad. Emerg. Med. 1997;4:44-51. PMID 9110011
  • Kini N and Strait RT. Non-Urgent Use of the Pediatric Emergency Department During the Day. Pediatr Emerg Care 1998;14:19-21. PMID 9516625
  • Havel C. Strait RT and Hennes HH. A clinical Trial of Propofol vs Midazolam for Procedural Sedation in a Pediatric Emergency Department. Academic Emerg Med. 1999;6-989-997. PMID 10530656
  • Strait RT, Kelly KJ and Kurup VP. Tumor Necrosis Factor a, Interleukin 1b and Interleukin 6 Levels in Febrile, Young Children With and Without Occult Bacteremia. Pediatrics 1999;104:1321-1326. PMID 10585983
  • Strait RT. A novel method for removal of penile zipper entrapment. Pediatr Emerg Care 1999;15:412-413. PMID 10608329
  • Kim MK, Strait RT, Sato TT and Hennes HM. A randomized clinical trial of analgesia in children with acute abdominal pain. Acad Emerg Med. 2002;9:281-287. PMID 11927450
  • Strait RT, Morris SC, Ying MY, Qu XW and Finkelman FD. Pathways of Anaphylaxis in the Mouse. J Allergy Clin Immunol. 2002;109:658-868. PMID 11941316
  • Strait RT, Morris SC, Smiley K, Urban JF and Finkelman FD. IL-4 exacerbates anaphylaxis. J.  Immunol. 2003;170:3835-3842. PMID 12646651
  • Brandt EB, Strait RT, Hershko D, Wang Q, Muntel EE, Scribner TA, Zimmermann N, Finkelman FD and Rothenberg ME. Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest 2003;112:1666-1677. PMID 14660743
  • Strait RT, Morris SC and Finkelman FD. IgG blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and FcgRIIb crosslinking. J Clin Invest 2006;116:833-841. PMID 16498503
  • Saito-Akei H, Brandt EB, Strait RT, Finkelman FD and Rothenberg ME. Epicutaneous aeroallergen exposure induces systemic Th2 immunity that predisposes to allergic nasal responses. J Allergy Clin Immunol. 2006;118:62-69. PMID 16815139
  • Forbes EE, Groschwit K, Abonia JP, Brand EB, Cohen E, Blanchard C, Ahrens R, Seidu L, McKenzie A, Strait RT, Finkelman FD, Foster PS, Matthaei K, Rothenberg ME, and Hogan SP. IL-9/mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. J Exp Med 2008;205:897-913. PMID 18378796
  • Khodoun M., Strait R., Orekov T., Hogan S., Debroski H., Köhl J., Finkelman FD. Peanuts can contribute to anaphylactic shock by activating complement. J Allergy Clin Immunol. 2009:123(2):342-51. PMID 19121857
  • Osterfeld H, Ahrens R, Strait R, Finkelman FD, Renauld JC, and Hogan SP. Differential roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxis. J Allergy Clin Immunol. 2010;125(2):469-476 PMID 20159257
  • Strait RT, Mahler A, Hogan SP, Khodoun MV, Shibuya A, Finkelman FD. Ingested allergens must be absorbed systemically to induce systemic anaphylaxis. J Allergy Clin Immunol.  2011 Apr;127(4):982-9.PMID 21354602
  • Reed J, Strait R, Kachelmeyer A, Huppert J. Biomarkers to distinguish ovarian torsion in females with lower quadrant abdominal pain. Acad Emerg Med. 2011 Jul;18(7):686-91. PMID 2176223
  • Khodoun MV, Strait RT, Armstrong L, Yanase N and Finkelman FD. Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis in the mouse. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12413-8. PMID 21746933
  • Strait RT, Hicks W, Barasa N, Mahler A, Khodoun M, Köhl J, Stringer K, Witte D, Van Rooijen N, Susskind BM and Finkelman FD. MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice. J Exp Med. 2011 Nov 21;208(12):2525-44 PMID 22025304
  • Ahrens R, Osterfeld H, Wu D, Chen C, Arumugam M, Groschwitz K, Strait R, Wang Y, Finkelman FD, and Hogan SP.  Intestinal mast cell levels control severity of oral antigen-induced anaphylaxis in mice. Am J Pathol. 2012 Apr;180(4):1535-46. PMID 22322300
  • Kucuk ZY, Strait R, Khodoun MV, Mahler A, Hogan S, Finkelman FD. Induction and suppression of allergic diarrhea and systemic anaphylaxis in a murine model of food allergy. J Allergy Clin Immunol. 2012 May;129(5):1343-8. PMID 22465213
  • Karsten CM, Pandey MJ, Figge J, Kilchenstein R, Taylor, Rosas M, McDonald JU, Orr S, Berger M, Petzold D, Blanchard V, Winkler A, Hess C, Reid DM, Majoul IV, Strait RT, Harris NL, Köhl G, Wollin L, Ludwig R, Zillikens D, Nimmerjahn F, Finkelman FD, Brown GD, Ehlers M, and Köhl J. Galactosylated IgG1 links FcgammaRIIB and Dectin-1 to block complement-mediated inflammation. Nature Medicine 2012 Sep;18(9):1401-6.PMID:22922409.
  • Khodoun M V, Kucuk ZY, Strait RT, Krishnamurthy D, Janek K, Lewkowich I, Morris SC, and Finkelman FD. Rapid polyclonal desensitization 1 with antibodies to IgE and FcεRIα. JACI 2013 Jun;131(6):1555-1564.PMID 23632296.
  • Khodoun MV*, Kucuk ZV*, Strait RT*, Krishnamurthy D, Janek K, Clay CD, Morris SC, Finkelman FD. Rapid desensitization of mice with anti-FcyR//b/FcyR/11 mAb safely presents lgG-mediated anaphylaxis. J Allergy Clin Immunol. 2013 Dec;132(6):1375-87. doi:10.1016/j.jaci.2013.09.008. Epub 2013 Oct 18. PMID:24139828 *all 3 authors contributed equally
  • Ulusoy C, Kim E, Tuzun E, Huda R, Yilmaz, Poulas K, Trakas N, Skriapa L, Niarchos A, Strait RT, Finkelman FD, Turan S, Zisimopoulou P, Tzartos S, Saruhan-Direskeneli, and Christadoss P. Preferential production of IgG1, IL-4 and IL-10 in MUSK-immunized mice. Clinical Immunology 2014 Apr; 151(2):155-163. PMID 24589747
  • Strait RT, Posgai MT, Mahler A, Barasa N, Jacob CO, Köhl J, Ehlers M, Stringer K, Shanmukappa SK, Witte D, Hossain MM, Khodoun M, Herr AB, and Finkelman FD. IgG1 protects against renal disease in a mouse model of cryoglobulinemia. Nature. 2015 Jan 22;517(7535):501-4. doi: 10.1038/nature13868. Epub 2014 Nov 2.PMID:25363774
  • Xiao C, Biagini Myers JM, Ji H, Metz K, Martin LJ, Lindsey M, He H, Powers R, Ulm A, Ruff B, Ericksen M, Somineni HK, Simmons J, Strait RT, Kercsmar CM, and Khurana Hershey GK. Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response. J Allergy Clin Immunol. 2015 Mar 28. pii: S0091-6749(15)00261-4. doi: 10.1016/j.jaci.2015.01.045 PMID:25910714
  • Huda R, Strait RT, Tüzün E, FinkelmanFD, and Christadoss P. IgG1 deficiency exacerbates experimental autoimmune mystenia gravis in BALB/c mice. J Neuroimmunology. J Neuroimmunol. 2015 Apr 15;281:68-72. doi:  10.1016/j.jneuroim.2015.03.004. Epub 2015 Mar 6.PMID 25867470
  • Strait RT, Thornton S and Finkelman FD. Cγ1 deficiency exacerbates collagen-induced arthritis. Arthritis & Rheumatology. Arthritis Rheumatol. 2016 Jan 27. doi: 10.1002/art.39611. [Epub ahead of print] PMID:26815845
  • Thornton S and Strait RT. Head-to-head comparison of protocol modifications for the generation of collagen-induced arthritis in a specific-pathogen free facility using DBA/1 mice. BioTechniques 60:119-128 (March 2016) doi 10.2144/000114388.
  • Kucukerden M, Huda R, Tuzun E, Yılmaz A, Skriapa L, Trakas N, Strait RT, Finkelman FD., Kabadayı S, Zisimopoulou P, Tzartos S, and Christadoss P, MuSK induced experimental autoimmune myasthenia gravis does not require IgG1 antibody to MuSK, Journal of Neuroimmunology 295–296 (2016) 84–92. doi: 10.1016/j.jneuroim.2016.04.003
  • Hasegawa K, Mansbach JM, Ajami NJ, Espinola JA, Henke DM, Petrosino JF, Piedra PA, Shaw CA, Sullivan AF, Camargo CA Jr, MARC-35 Investigators. Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitis. Eur Respir J 2016; 48: 1329-1339. PMID: 27799386
  • Clay CD, Strait RT, Mahler A, Khodoun MV, Finkelman FD.  Anti-FcγRIIB mAb suppresses murine IgG-dependent anaphylaxis by Fc domain targeting of FcγRIII. J Allergy Clin Immunol. 2018 Apr;141(4):1373-1381. PMID: 28624610
  • Epp A, Hobusch J, Bartsch YC, Petry J, Lilienthal GM, Koeleman CAM, Eschweiler S, Möbs C, Hall A, Morris SC, Braumann D, Engellenner C, Bitterling J, Rahmöller J, Leliavski A, Thurmann R, Collin M, Moremen KW, Strait RT, Blanchard V, Petersen A, Gemoll T, Habermann JK, Petersen F, Nandy A, Kahlert H, Hertl M, Wuhrer M, Pfützner W, Jappe U, Finkelman FD, Ehlers M. Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions. J Allergy Clin Immunol. 2018 Jan;141(1):399-402.e8. PMID:28728998
  • Hasegawa K, Piedra PA, Bauer CS, Celedón JC, Mansbach JM, Spergel JM, Espinola JA, Camargo CA Jr; MARC-35 Investigators. Nasopharyngeal CCL5 in infants with severe bronchiolitis and risk of recurrent wheezing: A multi-center prospective cohort study. Clin Exp Allergy. 2018 May 14. PMID:29756403
  • McAlles JW, Baker T, Kaur D, McKnight C, Lindsley A, Strait RT, Zhang X, Biagini Myers JM, Butsch Kovacic M, Lewkowich IP. Age and early maternal smoking contributes to epithelial cell IL-13 responsiveness in a pediatric asthma population. Allergy. 2019 May 18. Doi: 10.1111/all.13876. PMID: 31102477
  • Mansbach JM, Hasegawa K, Geller RJ, Espinola JA, Sullivan AF, Camargo CA Jr; MARC-35 Investigators. Bronchiolitis severity is related to recurrent wheezing by age 3 years in a prospective, multicenter cohort. Pediatr Res. 2019 Oct 4. doi: 10.1038/s41390-019-0589-z. PMID:31585458
  • McAlees J, Baker T, Houshe L, McKnight C, Lindsley A, Strait R, Zhang X, Biagini J, Butsch-Kovacic M, Lewkowich I. Increased responsiveness to IL-17A in pediatric asthmatics with high IgE, low traffic related air pollution exposure, and good asthma controlAuthorea. November 19, 2020. DOI: 10.22541/au.160579640.03001605/v1

books/chapters/invited papers/peer-reviewed reviews:

  • Strait RT and Ruddy RM. Informed Consent. In: Textbook of Pediatric Emergency Procedures.  Eds. Henretig FM and King C. Baltimore: Williams & Wilkins; 1997,p. 65-72.
  • Walsh-Kelly CM and Strait RT. Emergency Department and Hospital Protocols for Victims of Violence. Pediatr Clin North America 1998;45:445-457. PMID 9568023
  • Rosenberg NM, Knazik SR, Strait RT, Nadkami M. Decisions of King Solomon. Pediatr Emerg Care. 2001;17:364-368. PMID 11673718
  • Strait RT, Morris SC, and Finkelman FD. Cytokine Enhancement of Anaphylaxis. In: Anaphylaxis. Editors: Bock G and Goode J. Hoboken NJ: John Wiley and Sons, LTD; 2004, pgs 80-97. 
  • Strait R, Morrist SC, and Finkelman FD. Cytokine Enhancement of anaphylaxis. Novartis Found Symp. 2004;257:80-91;discussion 91-100, 276-85. PMID 15025393
  • Poirier MP, Isaacman DJ, Strait RT, Counselman FL and Foster RL. Pain and sedation. Pediatr Emerg Care. 2004:20;57-62. PMID 14716170
  • Finkelman FD, Shea-Donohue T, Morris SC, Gildea L, Strait RT, Madden KB and Urban JF, Jr. IL-4 and IL-13-mediated host protection against intestinal nematode parasites. Immunology in Review.2004;201:139-155. PMID 15361238
  • Hicks W, Strait RT, Finkelman FD, and Susskind BM. Transfusion-Related Acute Lung Injury (TRALI):History, Pathophysiology, and Role of the Clinical Laboratory. ASHI Quarterly 2004;28(3):92-95.
  • Finkelman FD, Rothenberg ME, Brandt EB, Morris SC and Strait RT. Molecular mechanism of anaphylaxis: Lessons from studies with murine models. J Allergy Clin Immunol. 2005;115:449-57. PMID 15753886
  • Hogan SP, Wang YH, Strait R, Finkelman FD Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity.Semin Immunopathol. 2012 Sep;34(5):643-53. PMID 22926692
  • Finkelman FD, Khodoun MV and Strait RT. Human IgE-independent systemic anaphylaxis.  J Allergy Clin Immunol. 2016 Jun;137(6):1674-80. doi: 0.1016/j.jaci.2016.02.015. Epub 2016 Apr 26.PMID:27130857
  • Strait RT, Camargo CA.Vitamin E and risk of childhood asthma. Expert Rev Respir Med. 2016 Aug;10(8):881-90. doi: 10.1080/17476348.2016.1184090. Epub 2016 May 13.PMID:27123996
  • Epp A, Sullivan KC, Herr AB and Strait RT. Immunoglobulin glycosylation effects in allergy and immunity. Current Allergy and Asthma Reports. Curr Allergy Asthma Rep. 2016 Nov;16(11):79. Review. PMID:27796794.

abstracts: 

  • Finkelman FD, Morris SC, and Strait RT. Pathways of anaphylaxis. NY AAAAI/EAACI Anaphylaxis Practall. April 2006.
  • Finkelman FD and Strait RT. IgG1 interacts with FcgRIIb and C3 to suppress murine immune complex (IC) disease. AAI annual mtg. Boston, MA, May 2006
  • Finkelman FD, Suskind BM and Strait RT. In vivo mouse models of TRALI. Joint CSTM Scientific Conference. Montreal, Canada. Spring 2006.
  • Strait RT, Meyer C, Lambris JD, Magotti P, and Finkelman FD. IgG1, IgG2a, complement and FcR in immune complex disease. AAI annual mtg. Miami, FL. Spring 2007
  • Strait RT and Finkelman FD. Lung Injury in a Mouse Model of TRALI Requires C3 and Macrophages but Not Neutrophils. PAS/SPR/APA annual spring meeting 2008. Honolulu, HI
  • Khodoun MV, Strait RT., Köhl J, and Finkelman FD. Why peanuts are a strong allergen. AAAAI Annual Meeting Philadelphia, PA  Spring, 2008,
  • Khodoun MV, Strait RT, Karasuyama H, Potter C, Mercatili P, Orekov T, and Finkelman FD Relative role of macrophages and basophiles in systemic anaphylaxis. AAI Annual Meeting, Seattle, WA Spring, 2009,
  • Khodoun MV, Strait RT, Orekov T, Hogan S, Herbert DR, Köhl J and Finkelman FD Peanuts can contribute to anaphylactic shock by activating complement. AAI Annual Meeting, Seattle, WA Spring, 2009.
  • Strait RT, Khodoun MV, Mahler A, Potter C, Koehl J and Finkelman FD Demonstration of a severe complement defect in FcRg-deficient mice AAI Seattle, WA, Spring 2009
  • Reed J, Strait RT and Hillard J, Evaluation of Females Presenting to the Pediatric Emergency Department with Lower Abdominal Pain. PAS Baltimore, MD Spring 2009
  • Mullins ES, Talmage KE, Flick MJ, Kombrinck KW, Strait RT, and Degen JL. Transfusion related acute lung injury (TRALI) is ameliorated by genetic elimination of fibrin(ogen) in mice, ASHI Fall 2009
  • Metz KA, Strait RT, Simmons J, Kercsmar C, Johnson L, Khurana-Hershey G. Application of Gene Expression Profiling to Children in the Setting of Asthma Exacerbation:  Lessons Learned. AAAAI Annual mtg, New Orleans, March 2010.
  • Ahrens R, Osterfeld H, Wu D, Groschwitz K, Arumugam M, Strait R, Rothenberg M, Finkelman F, and Hogan, S. Intestinal Mast cell levels determines oral antigen-induced anaphylaxis severity Collegium Internationale Allergologicum 28th Symposium, CIA symposium, Ischia Italy April 2010.
  • Khodoun MV, Strait RT, Armstrong L, Yanase N, Perkins C, Potter C, Herbert D, and Finkelman FD. Biomarkers of IgE- and IgG-dependent anaphylaxis AAI Baltimore, MD May 2010
  • Strait RT, Mahler A, Khodoun M, Hogan S, and Finkelman F, Serum but not secreted Ag-specific IgA inhibits oral Ag-induced anaphylaxis, AAI Baltimore, MD Spring 2010.
  • Khodoun MV, Krishnamurthy D, Strait RT, Kucuk Y, and Finkelman FD. Anti-FceRIa mAb-based therapy can suppress IgE-mediated disease. AAI San Francisco CA, Spring 2011
  • Strait RT, Mahler A, Barasa N, Herr A, Stringer K, Witte D and Finkelman FD. IgG1 protects against IgG3 immune complex mediated renal disease.AAI Boston MA, Spring 2012
  • Strait RT, Koehl J and Finkelman FD. Increased severity of murine anaphylaxis in the absence of signaling through the C3a and C5a receptors. AAI Pittsburgh, PA. Spring 2014
  • Khodoun M, Kiselev A, Mulloy J, Wunderlich M, Morris SC, Strait RT, and Finkelman FD. Suppression of IgE-mediated disease by rapid desensitization with anti-FceRIa mAb. AAI Pittsburgh, PA. Spring 2014.
  • Khodoun M, Gudimetla V, Krishnamurthy D, Strait RT, and Finkelman FD. Mechanism of food allergy induction by medium chain triglycerides (MCT). AAI Pittsburgh, PA. Spring 2014.
  • Strait RT and Thornton S. Specific variations in the protocol for the induction of collagen-induced arthritis in mice improve reproducibility of disease severity and incidence in an SPF facility. AAI New Orleans, LA, Spring 2015

invited lectures:

  • IgA and Anaphylaxis. Digestive Health Center Annual Scientific Retreat. Cincinnati Children’s Hospital, February 2008.
  • Mouse model of TRALI. Center for Immunological Research Annual Retreat.Cincinnati Chidren’s Hospital,  June 2008.
  • Threshold modeling in TRALI. Immunohematology Seminar Series, Cincinnati Children’s Hospital, March 11, 2013
  • Complement plays a surprising role in anaphylaxis. Center for Immunological Research Annual Retreat, Cincinnati Ohio, October, 2014

awards, honors or organizations

member: 

  • American Academy of Pediatrics
  • American Medical Association

get to know me

I chose my specialty because...

I enjoy working with and caring for children.


I like working with kids because...

they have a natural positive attitude and approach life with euthusiasm and joy.


I chose to work at Dayton Children's because...

the employees share my love for children and enjoy working here.


Dayton Children's is special because...

of the people that work here.


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