specific aims
The brain tumor microenvironment is heterogeneous, with variable features of hypoxia, acidosis, nutrient depletion, and stromal and immune cell signaling. These have clear effects on the hallmarks of tumor growth, invasion, and migration, but have not been well characterized in the context of in vivo imaging and preclinical cell culture models.
The specific aims of our research over the next three years will test the overarching hypothesis that microenvironmental stressors along with stromal and immune components can:
- Be identified on in vivo clinical imaging and categorized by machine learning for brain tumor diagnosis, prognosis, and treatment design.
- Alter cell proliferation, invasion, migration, and treatment resistance of cultured cells used in preclinical models.
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