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Lionel Chow, MD, PhD

expertise

neuro-oncology

bio

Lionel Chow, MD, PhD is a pediatric hematologist and oncologist at Dayton Children's with an expertise in childhood brain cancer. Dr. Chow works closely with families and colleagues to ensure that children with brain cancer and their families receive the best care and treatment possible.

Languages spoken:

  • English
  • French
  • Taiwanese

education and training

  • medical school: McGill University, Canada
  • residency: The Hospital for Sick Children, Toronto - Pediatrics
  • fellowship: 
    • The Hospital for Sick Children, Toronto - pediatric hematology and oncology
    • St. Jude Children's Research Hospital, Memphis - pediatric neuro-oncology
  • board certification: general pediatrics

publications and presentations

  • Chow, L.M.L., M.J.H. Ratcliffe and A. Veillette. (1992) tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene. Mol. Cell. Biol. 12:1226-1233. PMID: 1545804; PMCID: PMC369554
  • Davidson, D., L.M.L. Chow, M. Fournel and A. Veillette. (1992) Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn. J. Exp. Med. 175:1483-1492. PMID: 1375262; PMCID: PMC2119231.
  • Chow, L.M.L., M. Fournel, D. Davidson and A. Veillette. (1993) Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk. Nature 365:156-160. PMID: 8371758.
  • Gervais, F.G., L.M.L. Chow, J.M. Lee, P.E. Branton and A. Veillette. (1993) The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site. Mol. Cell. Biol. 13:7112-7121. PubMed PMID: 8413300; PMCID: PMC364772.
  • Chow, L.M.L., C. Jarvis, Q. Hu, S.H. Nye, F.G. Gervais, A. Veillette and L.A. Matis. (1994) Ntk: A Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 91:4975-4979. PubMed PMID: 8197166; PMCID: PMC43912.
  • Chow, L.M.L., D. Davidson, M. Fournel, P. Gosselin, S. Lemieux, M.S. Lyu, C.A. Kozak, L.A. Matis and A. Veillette. (1994) Two distinct protein isoforms are encoded by ntk, a csk-related tyrosine protein kinase gene. Oncogene 9:3437-3448. PMID: 7970703.
  • Chow, L.M.L., and A. Veillette. (1995) The Src and Csk families of tyrosine protein kinases in hemopoietic cells. Semin. Immunol. 7:207-226. PMID: 8520026.
  • Cloutier, J.-F., L.M.L. Chow and A. Veillette. (1995) Requirement of the SH3 and SH2 domains for the inhibitory function of tyrosine protein kinase p50csk in T-lymphocytes. Mol. Cell. Biol. 15:5937-5944. PMID: 7565746; PMCID: PMC230845.
  • Latour, S., L.M.L. Chow and A. Veillette. (1996) Differential intrinsic activity of Syk and Zap-70 protein-tyrosine kinases. J. Biol. Chem. 271:22782-22790. PMID: 8798454.
  • Davidson, D., L.M.L. Chow and A. Veillette. (1997) Chk, a Csk family tyrosine protein kinase, exhibits Csk-like activity in fibroblasts, but not in an antigen-specific T-cell line. J. Biol. Chem. 272:1355-1362. PMID: 8995444.
  • Treacy, E.P., B.R. Akerman, L.M.L. Chow, R. Youil, C. Bibeau, J. Lin, A.G. Bruce, M. Knight, D.M. Danks, J.R. Cashman and S.M. Forrest. (1998) Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethyaminuria, a defect in detoxification. Hum. Mol. Genet. 7:839-845. PMID: 9536088
  • Akerman, B.R., S.M. Forrest, L.M.L. Chow, R. Youil, M. Knight and E.P. Treacy. (1999) Two novel mutations of the FMO3 gene in a proband with trimethylaminuria. Hum. Mutat. 13:376-379. PMID: 10338091
  • Akerman, B.R., H. Lemass, L.M.L. Chow, D.M. Lambert, C. Greenberg, C. Bibeau, O.A. Mamer and E.P. Treacy. (1999) Trimethyaminuria is caused by mutations of the FMO3 gene in a North American cohort. Mol. Genet. Metab. 68:24-31. PMID: 10479479
  • Chow, L.M.L., J.N. Friedman, C. MacArthur, R. Restrepo, M. Temple, P.G. Chait and B. Connolly. (2003) Peripherally inserted central catheter (PICC) fracture and embolization in the pediatric population. J. Pediatr. 142:141-144. PMID: 12584534
  • Chow, L.M.L., M. Capra, Z. Levichek, G. Koren and R.M. Grant. (2004) Toxic ingestion of 6-mercaptopurine by young siblings of pediatric oncology patients. J. Pediatr. 144:669-671. PMID: 15127011
  • Chow, L.M.L. and S.J. Baker. (2006) PTEN function in normal and neoplastic growth. Cancer Lett. 241:184-196. PMID: 16412571
  • Chow, L.M.L., Y. Tian, T. Weber, M. Corbett, J. Zuo and S.J. Baker. (2006) Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells. Dev. Dyn. 235:2991-2998. PMID: 16958097.
  • Chow, L.M.L., P.C. Nathan, D.C. Hodgson, D. Jenkin, S. Weitzman, R.M. Grant, D. Manson, A. Bross, J.J. Doyle, C. Danjoux and M. Greenberg. (2006) Survival and late effects in children with Hodgkin’s lymphoma treated with MOPP/ABV and low-dose, extended-field irradiation. J. Clin. Oncol. 24:5735-5741. PMID: 17179107
  • Weber, T., M.K. Corbett, L.M.L. Chow, M.B. Valentine, S.J. Baker and J. Zuo. (2008) Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells. Proc. Natl. Acad. Sci. U.S.A. (2008) Jan 15;105(2):781-5. PMID: 18178626; PMCID: PMC2206613
  • Chow, L.M.L., J. Zhang and S.J. Baker. (2008) Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells. Transgenic Res. 17:919-928. PMID: 18483774; PMCID: PMC2522290.
  • Cicero, S.A., D. Johnson, S. Reyntjens, S. Frase, S. Connell, L.M.L. Chow, S.J. Baker, B.P. Sorrentino and M.A. Dyer (2009) Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 106:6685-6690. PMID: 19346468; PMCID: PMC2672506.
  • Lavado, A., O. Lagutin, L.M.L. Chow, S.J. Baker and G. Oliver. (2010) Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol. 8:e1000460. PMID: 20808958; PMCID: PMC2923090
  • Chow, L.M.L., R. Endersby, X. Zhu, S. Rankin, C. Qu, J. Zhang, A. Broniscer, D.W. Ellison and S. J. Baker. (2011) Cooperativity within and among Pten, p53 and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell 19:305-316. PMID: 21397855; PMCID: PMC3060664
  • Dorris, K., M. Fouladi, S.M. Davies, J. Perentesis, J.M. Lawrence, L.M.L. Chow, A. Assa’ad, B. Uygungil and S. Jodele. (2011) Severe delayed-type allergic reaction to thiol-based chemoprotective agents mesna and amifostine in a child with a supratentorial primitive neuroectodermal tumor. J. Pediatr. Hematol. Oncol. 33:e250-252. PMID: 21646919
  • Elmeliegy, M.A., A.M. Carcaboso, L.M.L. Chow, Z.M. Zhang, C. Calabrese, S.L. Throm, F. Wang, S.J. Baker and C.F. Stewart. (2011) Magnetic resonance imaging (MRI)-guided microdialysis cannula implantation in a spontaneous high-grade glioma murine model. J. Pharm. Sci. 100:4210-4214. PMID: 21837651; PMCID: PMC3750095
  • Chow, L.M.L. and S.J. Baker. (2012) Capturing the molecular and biological diversity of high-grade astrocytoma in genetically engineered mouse models. Oncotarget 3:67-77. PMID: 22287481; PMCID: PMC3292893
  • Zhu, G., L.M.L. Chow, I.T. Bayazitov, Y. Tong, R.J. Gilbertson, S.S. Zakharenko, D.J. Solecki and S.J. Baker. (2012) Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects. Development 139:3422-3431. PMID: 22874917; PMCID: PMC3424045
  • Hummel, T.R., L.M.L. Chow, M. Fouladi and D. Franz. (2013) Pharmacotherapeutic management of pediatric astrocytomas: current and upcoming strategies. Pediatric Drugs 15:29-42. PMID: 23329387
  • Joshi, K., Y. Banasavadi-Siddegowda, X. Mo, S.H. Kim, P. Mao, C. Kig, D. Nardini, R.W. Sobol, L.M.L. Chow, H.I. Kornblum, R. Waclaw, M. Beullens and I. Nakano. (2013) MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Stem Cells 31:1051-1063. PMID: 23404835; PMCID: PMC3744761.
  • Zhong, Y., Y.-W. Wan, K. Pang, L.M.L. Chow and Z. Liu. (2013) Digital sorting of complex tissues for cell type-specific gene expression profiles. BMC Bioinformatics 14:89. PMID: 23497278; PMCID: PMC3626856.
  • Rafalski, V.A., P.P. Ho, J.O. Brett, D. Ucar, J.C. Dugas, E.A. Pollina, L.M.L. Chow, A. Ibrahim, S.J. Baker, B.A. Barres, L. Steinman and A. Brunet. (2013) Expansion of oligodendrocyte progenitor cells upon SIRT1 inactivation in the adult brain. Nature Cell Biol. 15:614-624. PMID: 23644469; PMCID: PMC4026158
  • Wojton, J., Z. Chu, H. Mathsyaraja, W.H. Meisen, N. Denton, C.-H. Kwon, L.M.L. Chow, M. Palascak, R. Franco, T. Bourdeau, S. Thornton, M.C. Ostrowski, B. Kaur and X. Qi. (2013) Systemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma. Mol. Ther. 21:1517-1525. PMID: 23732993; PMCID: PMC3734660.
  • Liu, X., R.R. Chhipa, S. Pooya, M. Wortman, S. Yachyshin, L.M.L. Chow, A. Kumar, X. Zhou, Y. Sun, B. Quinn, C. McPherson, R.E. Warnick, A. Kendler, S. Giri, J. Poels, K. Norga, B. Viollet, G.A. Grabowski and B Dasgupta. (2014) Discrete mechanism of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. Proc. Natl. Acad. Sci. U.S.A. 111:E435-444. PMID: 24474794; PMCID: PMC3910576
  • Salloum, R., M. DeWire, A. Lane, S. Goldman, T. Hummel, L. Chow, L. Miles, M. Sutton, C. Stevenson, M. Fouladi and J. Leach. (2015) Patterns of progression in pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma treated with bevacizumab-based therapy at diagnosis. J. Neurooncol. 121:591-598. PMID: 25433556
  • Gass, D., M. DeWire, L. Chow, S.R. Rose, S. Lawson, C. Stevenson, A.L. Pai, B. Jones, M. Sutton, A. Lane, D. Pruitt, M. Fouladi and T.R. Hummel. (2015) Pediatric tectal plate gliomas: a review of clinical outcomes, endocrinopathies, and neuropsychological sequelae. J. Neurooncol. 122:169-177. PMID: 25582835.
  • Dave, N., L.M.L. Chow, G.A. Gudelsky, K. LaSance, X. Qi and P.B. Desai. (2015) Pre-clinical pharmacological evaluation of letrozole as a novel treatment for gliomas. Mol. Cancer Ther. 14:857-864. PMID: 25695958; PMCID: PMC4631403
  • Hummel, T.R., R. Salloum, R. Drissi, S. Kumar, M. Sobo, S. Goldman, A. Pai, J. Leach, A. Lane, D. Pruitt, M. Sutton, L.M.L. Chow, L. Grimme, R. Doughman, L. Backus, L. Miles, C. Stevenson, M. Fouladi and M. DeWire. (2015) A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas. J. Neurooncol. 127:53-61. PMID: 26626490
  • Hoffman, L.M., M. DeWire, S. Ryall, P. Buczkowicz, J. Leach, L. Miles, A. Ramani, M. Brudno, S.S. Kumar, R. Drissi, P. Dexheimer, R. Salloum, L. Chow, T. Hummel, C. Stevenson, Q.R. Lu, B. Jones, D. Witte, B. Aronow, C.E. Hawkins and M. Fouladi. (2016) Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta Neuropathol. Commun. 4:1. PMID: 26727948; PMCID: PMC4700584
  • Steed, T.C., J.M. Treiber, K. Patel, V. Ramakrishnan, A. Merk, A.R. Smith, B.S. Carter, A.M. Dale, L.M.L. Chow and C.C. Chen. (2016) Differential localization of glioblastoma subtype: implications on glioblastoma pathogenesis. Oncotarget 7:24899-24907. PMID: 27056901; PMCID: PMC5041878
  • Zhu, G., S.L. Rankin, J.D. Larson, X. Zhu, L.M.L. Chow, C. Qu, J. Zhang, D.W. Ellison and S.J. Baker. (2017) PTEN signaling in the postnatal perivascular progenitor niche drives medulloblastoma formation. Cancer Res. 77:123-133. PMID: 27815386; PMCID: PMC5214974
  • Anderson, J., R. Muraleedharan, N. Oatman, A. Klotter, S. Sengupta, R.R. Waclaw, J. Wu, R. Drissi, L. Miles, E.H. Raabe, M. Weirauch, M. Fouladi, L.M.L. Chow, L. Hoffman, M. DeWire and B. Dasgupta. (2017) The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Neuro-Oncol. 19:1068-1078. PMID: 28339768; PMCID: PMC5570182
  • Salloum, R., M.K. McConechy, L.G. Mikael, C. Fuller, R. Drissi, M. DeWire, H. Nikbakht, N. De Jay, X. Yang, D. Boue, L.M.L. Chow, J.L. Finlay, T. Gayden, J. Karamchandani, T.R. Hummel, R. Olshefski, D.S. Osorio, C. Stevenson, C.L. Kleinman, J. Majewski, M. Fouladi and N. Jabado. (2017) Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Acta Neuropathol. Commun. 5:78. PMID: 29084603; PMCID: PMC5663045
  • Sengupta, S., M. Sobo, K. Lee, S.S. Kumar, A.R. White, I. Mender, C. Fuller, L.M.L. Chow, M. Fouladi, J.W. Shay and R. Drissi. (2018) Induced telomere damage to treat telomerase expressing therapy-resistant pediatric brain tumors. Mol. Cancer Ther. 17:1504-1514. PMID: 29654065
  • Chadwick, M.L., A. Lane, D. Thomas, A.R. Smith, A.R. White, D. Davidson, Y. Feng, E. Boscolo, Y. Zheng, D.M. Adams, A. Gupta, A. Veillette and L.M.L. Chow. (2018) Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Oncotarget 9:24750-24765. PMID: 29872503; PMCID: PMC5973867
  • Chhipa, R.R., Q. Fan, J. Anderson, R. Muraleedharan, Y. Huang, G. Ciraolo, X. Chen, R. Waclaw, L.M.L. Chow, Z. Khuchua, M. Kofron, M.T. Weirauch, A. Kendler, C. McPherson, N. Ratner, I. Nakano, N. Dasgupta, K. Komurov and B. Dasgupta. (2018) AMP kinase promotes glioblastoma bioenergetics and tumor growth. Nature Cell Biol. 20:823-835. PMID: 29915361

awards, honors and organizations

  • Fellow of the Royal College of Physicians of Canada

organizations:

  • American Association for the Advancement of Science
  • American Association of Cancer Research
  • American Society of Clinical Oncology
  • Society for Neuro-Oncology
  • Children's Oncology Group

get to know me

I chose my specialty because...

I chose pediatric hematology and oncology because cancer and blood diseases are the number one cause of non-accidental death in children in the United States. My focus is ensuring children with these diseases get the best treatment possible. I am also dedicated to finding new and better treatments and cures for childhood brain cancer.


I like working with kids because...

they are full of wonder, they are resilient and they are inspiring.


I chose to work at Dayton Children's because...

the hospital is going through exciting changes and growth that will make this an even better place for children to receive their care.


Dayton Children's is special because...

it is a hospital that has the expertise and facilities of a large pediatric center while maintaining the familiarity and personal attention of smaller hospitals.


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