2010-2011

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Research

Because kids count, research continues

Research to improve the quality of care for the children who count on us remains a priority at Dayton Children’s. Throughout the hospital, research is underway by physicians, nurses and other staff to help all pediatric practitioners provide more effective treatments.

Research at Dayton Children’s is conducted by

  • Physicians and staff affiliated with Wright State University Boonshoft School of Medicine (WSUBSOM)
  • Staff of Dayton Children’s
  • Dayton Children’s Clinical Trials (DCCT)

Highlights from the WSUBSOM academic report – 2010

  • Wright State University faculty and members of the Dayton Children’s professional staff continue to publish papers in excellent peer-reviewed journals and continue to be very well represented presenting papers and posters at major national meetings. Dayton Children’s pediatric residents and WSUBSOM medical students participate in many of the research programs.
  • The percentage—13.4 percent—of the Wright State University Boonshoft School of Medicine class of 2011 selecting pediatrics as a career surpassed the national average of 11 percent. This makes pediatrics one of the top choices of the school’s medical students.
  • Our pediatric residency program received a full five-year accreditation from the Accreditation Council for Graduate Medical Education (ACGME). Many programs receive just a three- to four-year accreditation.
  • Ann Burke, MD,program director of medical education, begins her term as president of the Association of Pediatric Program Directors.
  • Navjyot Vidwan, MD, joins Dayton Children’s division of infectious disease and WSUBSOM’s department of pediatrics.
  • Ann Burke, MD; Shalini Forbis, MD;and Abiodun Omoloja, MD, are promoted to the rank of associate professor; James Stark, MD, is promoted to the rank of professor.
  • SOAR-Net,the WSUBSOM/Dayton Children’s Practice Based Research Network, receives national attention for its research into the relationship between type of healthcare coverage and accessing recommended healthcare services.
  • Emmett Broxson, MD,director of hematology/oncology, is awarded the Dayton Children’s Wallace B. Taggart Award. The award recognized him for his outstanding service for the well-being of children.
  • Amit Vohra, MD,receives a Presidential Citation for outstanding contributions to the Society of Critical Care Medicine.
  • Maria Nanagas, MD,director, Children’s Health Clinic, receives Dayton Children’s Distinguished Service Award, and the 2010 American Academy of Pediatrics Special Achievement Award.
  • Gregory Toussaint, MD,receives the Teaching Excellence Award from the WSUBSOM class of 2011.
  • Marc Raslich, MD, receives the 2010 WSUBSOM Faculty Development Award.
  • Gregory Eberhart, MD, receives the Dayton Children’s A Child’s Voice Award for his work in advocating for the health of children in our community.

Grants and contracts

Sherman Alter, MD, medical director of infectious disease

  • A Phase 3, randomized, double-blind, multicenter study to compare the efficacy and safety of Micafungin versus Amphotericin B Deoxycholate for the treatment of neonatal candidiasis.Astellas Pharma US, Inc. (APUS). $20,000.

Ann Burke, MD, program director of medical education             

  • Assessment of work-life balance among pediatric residents (with Gordon MB, Bogart L, Chaing VW, Johnson C, Landrigan C, Sectish TC, Schuster M.).Association of Pediatric Program Directors (APPD) Special Projects Program. March 2009;$9,945/twoyears.

Paul Breyer, MD, director of endocrinology and metabolism

  • Parents’ social capital and their children’s glycosylated hemoglobin (HbA1c). Dayton Children’s Research Foundation. Principal investigator. $27,000/two years.

Emmett Broxson, MD, director of hematology/oncology

  • Dayton Children’s; Children’s OncologyGroup.Principalinvestigator.2000-present; $271,897.

Mukund Dole, MD, hematology/oncology

  • Region II Comprehensive Sickle Cell Program funding.Ohio Department of Health. $85,058.

Robert Fink, MD, director of pulmonary medicine                       

  • Cystic Fibrosis (CF) Center Grant. CF Foundation.Center director.$85,000/year.
  • CF Research Development Grant. CF TDN Network. Principal investigator. $70,000/year.
  • Ohio Newborn CF Screening Grant. State of Ohio. Program director. $50,000/year.
  • The EPIC observational study: longitudinal assessment of risk factors for and impact of Pseudomonas aeruginosa. Acquisition and early anti-Pseudomonal treatment in children with CF (EPIC-002). Cystic Fibrosis FoundationTherapeutics, Inc.Principal investigator. 5% effort.
  • 2008-present
    • A phase 3, international, multi-center, randomized, double-blind, placebo-controlled, parallel-group, efficacy and safety study of Denufosol Tetrasodium Inhalation Solution in patients with cystic fibrosis lung disease and FEV1 ≥75% but ≤110% Predicted; Tiger-2 08-110.Inspire Pharmaceuticals, Inc. Principal investigator.5% effort.
  • 2009-present
    • Cystic fibrosis therapeutics development network center grant.Cystic Fibrosis Foundation Therapeutics, Inc.Principal investigator.10% effort. $70,000/year. 
  • 2009-2010
    • A phase 2, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the safety and efficacy of VX-770 in subjects aged 12 years and older with cystic fibrosis who are homozygous for the F508del-CFTR mutation (VX08-770-104. Vertex Pharmaceuticals, Inc. Principal investigator.
    • An open-label, randomized phase 3 trial to evaluate the efficacy and safety of Aztreonam for inhalation solution versus Tobramycin inhalation solution in an intermittent aerosolized antibiotic regimen in patients with cystic fibrosis. Gilead Sciences, Inc. Principal Investigator.
  • 2009-2011
    • Open-label extension of study 08-110 - amulticenter study of Denufosol Tetrasodium inhalation solution in patients with cystic fibrosis lung disease (08-114). Inspire Pharmaceuticals, Inc.Principal investigator.
  • 2008-2010
    • A Phase 3, international, multicenter, randomized, double-blind, placebo-controlled, parallel-group efficacy and safety study of Denufosol Tetrasodium Inhalation Solution in patients with cystic fibrosis lung disease and FEV1≥75% but ≤110% Predicted (08-110). Inspire Pharmaceuticals, Inc.Principal investigator.

Shalini Forbis, MD, general pediatrics

  • Evaluate the association between parental health literacy and knowledge of child’s cardiac condition. Dayton Children’s Foundation Grant.Principal investigator. August 2010-2011.
  • A pilot study to evaluate the impact of implementing a comprehensive health literacy intervention in a clinical setting. Boonshoft Innovation Fund, Wright State University Boonshoft School of Medicine Grant.Principal investigator. 2008-2010.
  • Improve the research infrastructure of the Division of General Pediatrics at Wright State University Boonshoft School of Medicine Health Resources and Services Administration, Academic Administrative Unit.  Co-investigator.2008-2011.

James French, MD, hematology/oncology 

  • A post-authorization safety surveillance study of Xyntha in usual care settings. W Wyeth Pharmaceuticals, Inc. (acting through its division Wyeth Research,A Pfizer Company). 2008-ongoing.
  • Universal data collection on complications of hemophilia and serum testing and storage. Centers for Disease Control and Prevention. 1999-ongoing.
  • Multicenter Hemophilia Cohort Study (MHCS-II). National Cancer Institute. 2000-2005. Open for data analysis only.
  • Thromboembolism registry. Hemostasis and Thrombosis Research Society. 2006-ongoing.
  • Assessment of acute and chronic pain in patients with bleeding disorders. Munson Medical Center and Henry Ford Hospitals HTCs. IRB exempt.Ongoing.
  • A multicenter, open-label, non-controlled trial on safety and efficacy of N8 in prevention and treatment of bleeds in previously treated subject with hemophilia A. Novo Nordisk, Inc. 2010.Waiting IRB approval.

Eileen Kasten, MD, director of developmental pediatrics

  • Comprehensive clinical phenotyping and genetic mapping for the discovery of autism susceptibility genes. Subcontract with Nationwide Children’s Hospital.

Gogi Kumar, MD, neurology

  • A multicenter, double-blind, randomized, placebo-controlled, 4-armed Merck headache study: Parallel group study to evaluate the efficacy of Zolmitriptan 0.5-, 2.5- and 5-mg nasal spray in the treatment of acute migraine headache in adolescents. Merck Clinical Study. Open using rizatriptan in 12-17-year-olds. Sub-investigator.

Daniel Lacey, MD, PhD, neurology 

  • A worldwide, open-label, clinical trial to examine the safety and tolerability of rizatriptan in pediatric migraneur. Merck MK-0462, 086-01. 2009-present.
  • A worldwide, randomized, double-blind, placebo-controlled parallel group clinical trial to evaluate the safety and efficacy of rizatriptan for the acute treatment of migraine in children and adolescents. Merck MK-0462, 082. 2009-present.

Sonia Michail, MD, gastroenterology and nutrition

  • The use of VSL#3 in children with irritable bowel syndrome.NIH R21 grant.January 2008. Direct cost: $400,000/three years. NIH NCCAM grant # 667122, NIH R21 AT003400-02.
  • The use of Affymetrix in studying microflora of children with irritable bowel syndrome. NIH R21 grant.Co-principal investigator.$300,000/two years. NIH NCCAM 1R21AT003423-01A2.
  • Identifying stool microflora in healthy and obese children with type II diabetes. Dayton Area Graduate Medical Education grant.Submitted by Katie Ellgass, MD (pediatric resident).Budget: $3,500.
  • The use of GeneChip Technology in studying microflora. Dayton Children’s Research Foundation. Principal investigator. September 2008; $40,000/two years.

Marvin Miller, MD, director of medical genetics

  • Ohio State Genetics Service Grant. Principal investigator. July 1, 2008-June 30, 2010; $226,000.
  • Bone density measurements in children using spiral CT. Dayton Children’s Research Foundation. Co-investigator. 2008-2011; $39,904/two years.

Maria Nanagas, MD, director, Children’s Health Clinic    

  • Reach Out and Read Program. $3,000. 

Abiodun Omoloja, MD, nephrology

  • Tobacco use and secondhand smoking (SHS) in children enrolled in chronic kidney disease cohort (CKiD). Dayton Children’s Research Foundation. Principal-investigator. 2009-2010; $40,000.

Gary Onady, MD, PhD, internal medicine/pediatrics       

  • Cystic Fibrosis Center Grant. Cystic Fibrosis Foundation.2009-2010;$6,000.

John Pascoe, MD, general pediatrics

  • Academic Administrative Unit, Pediatrics – Project Director. Health Resources and Services Administration (Training in Primary Care Medicine and Dentistry). $698,206/ three years.
  • Parents’ social capital and their children’s glycosylated hemoglobin (HbA1c). Dayton Children’s Research Foundation. Co-principal investigator. $27,000.
  • Best practices for study recruiting in primary care settings.National Institutes of Health (sub-contract from Wayne State University). $67,351/two years.

Ruthann Pfau, medical genetics     

  • Regional Comprehensive Genetics Centers Program, Ohio Department of Health. Manager. 2011; $226,200/year.

Marc Raslich, MD, internal medicine

  • 2008 – 2010 Boonshoft Innovation Fund. Child Health Equity Project, Wright State University, site coordinator, University Medicine – Pediatrics. (S. Forbis, PI)

James Stark, MD, pulmonary medicine      

  • Genetic determinants of RSV susceptibility in mice. Research Challenge Award,Wright State University Boonshoft School of Medicine. Principal investigator. September 1, 2006-September 30, 2009;total costs (contract): $20,000.

Navjyot Vidwan, MD, infectious disease    

  • Prevalence of chlamydia trachomatis infection from maternal transmission to the neonate. NIH Fogarty International Clinical Fellows Research Grant Award. Funded by NIH Fogarty;conducted at Christian Medical College, Vellore, India. Principal investigator. Mentor: Mark Steinhoff, MD. October 2008 - current.

Lori Vavul-Roediger, MD, child advocacy

  • Victims of Crime Act (VOCA), Ohio State Attorney General Office.October 2010-September 2011;$85,382.



 

Research

Publications and papers

Alter SJ. Immunization Update 2010. Prim Care Rep. 2010;16(11):1-10.

Stork L, Matloub Y, Broxson EH, et al. Oral 6-Mercaptopurine vs. Oral 6-Thioguanine and veno-occlusive disease in children with standard risk acute lymphoblastic leukemia: Report of the Children’s Oncology Group CCG 1952-clinical trial [published online ahead of print February 1, 2010].Blood. 2010;115(14):2740-2748.

Hicks PJ, Englander R, Schumacher DJ, Burke AE,et al. Pediatric milestone project: next steps toward meaningful outcomes assessment. J Grad Med Ed. 2010;2(4):577-84.

Carraccio C, Burke AE. Beyond competencies and milestones: adding meaning through context. J Grad Med Ed. 2010;2(3):419-422.

Englander R, Hicks P, Benson B and the Pediatric Milestone Project Working Group (Burke AE, Carraccio C, Guralnick S, et al). Pediatrics milestones: a developmental approach to the competencies. J Pediatrics.2010;157(4):521-2.

Hicks PJ, Schumacher DJ, Benson, BJ, Burke AE, et al. The Pediatric milestones: conceptual framework, guiding principles, and approach to development. J Grad Med Ed. 2010;2(3):410-418.

Burke AE, Rushton J, Guralnick S, et al. Resident work duty hour requirements: medical educators’ perspectives. Academic Pediatrics. 2010;10:369-71.

Li ST, Burke AE. Individualized learning plans: basics and beyond. Academic Pediatrics. 2010;10:289-292.

Burke AE, Guralnick S, Hicks PJ. The Association of Pediatric Program Directors’ strategic plan: an opportunity for transformational change. Academic Pediatrics. 2010;10:220-1.

Fernandes AK.The loss of dignity at the end of life: incommunicability as a call and a demand. National Catholic Bioethics Quarterly. 2010:529-546.

Fernandes AK.Suffering in the context of euthanasia and assisted suicide: transcending Job through Wojtyla’s anthropology. Christian Bioethics. 2010;16(3):1-17.

Lacey DJ. Adolescents with chronic daily headaches: other co-morbid pain disorders. Headache.2010;50(S1):42.

Michail S, Stolfi A. Expert commentary: functional abdominal pain in children; is it diet related?  Evidence-Based Child Health: A Cochrane Review Journal.In press.

Tschudy J, Michail S.Disseminated histoplasmosis and pneumocystis pneumonia in a child with Crohn’s disease receiving infliximab. J Pediatr Gastroenterology and Nutrition. 2010;51(2):221-222.

Miller R,Miller ME. Overrepresentation of males in traumatic brain injury of infancy and in infants with macrocephaly: further evidence that questions the existence of shaken baby syndrome. American Journal of Forensic Medicine and Pathology.2010;31:165-173.


Plunkett J, Miller ME,et al. Guidance for shaken baby syndrome testimony. Rapid Response. British Medical Journal. Published July 8, 2010.

Gabaeff S, Bohan T, Miller ME, et al. Flawed logic [letter]. Minnesota Medicine. 2010;93(2):6-7.

Hyman CJ, Ayoub D, Miller ME.Response to VinchonChild’s Nervous System [letter].doi 10.1007/s00381-010-1337-1.

Omoloja A, Ey E, Nguyen D, Canessa L. Abdominal pain in a female adolescent [published online ahead of print June 17, 2010]. Pediatr Nephrol.

Omoloja A, Chand D, Greenbaum L, Wilson A, Bastian V, Ferris M, Bernert J, Stolfi A,et al. Cigarette smoking and second-hand smoking exposure in adolescents with chronic kidney disease: a study from the Midwest Pediatric Nephrology Consortium[published online ahead of print August 4, 2010]. Nephrol Dial Transplant.

Moran A, Brunzell C, Cohen RC, Katz M, Marshall BC, Onady G, et al. Clinical care guidelines for cystic fibrosis-related diabetes. Diabetes Care. 2010;33:2697-2708.

Onady GM.(2010) Hailey’s Here, Copyright, BMI Nashville, TN (a music publication)

Pascoe JM, Lee M, Specht SL, et al. Mothers with positive or negative depression screens evaluate a maternal resource guide. J Pediatr Health Care. 2010;24(6):378-84.

Johnson K, Raslich MA.Childhood predictors of adult type 2 diabetes [editorial]. AAP Grand Rounds. 2010;24:1.

Velasco JW, Raslich MA. ECG testing prior to college sports participation [editorial]. AAP Grand Rounds. 2010;24:1 

Stark JM, Barmada MM, Winterberg AV, et al. Genomewide association analysis of severe respiratory syncytial virus infection.J Virology. 2010;84:2257-2269.

McConnell E, Clasen C, Stolfi A, Anderson D, Markert RJ, Jaballas E. Community service and the pediatric exam: an introduction to clinical medicine via a partnership between first year medical students and a community elementary school. Teach Learn Med. 2010;22:187-190.

Hershberger PJ, Rodes MB, Zyrd TW, Stolfi A.Professionalism: self-control matters.Med Teach.2010;32:e36-e41.

Koles PG, Stolfi A,Borges NJ, et al. The impact of team-based learning on medical students' academic performance. Acad Med. 2010;85:1739-1745.

Jaballas E, Clark-Ott D, Clasen C, Stolfi A, et al. Parents’ perceptions of their children’s weight, eating habits, and physical activities at home and at school. J Pediatr Health Care.In press.

Calabria CW, Stolfi A, Tankersley MS. Recognizing and evaluating periodic local reactions in allergy immunotherapy and associated systemic reactions. Ann Allergy Asthma Immunol.In press.

Books and chapters

Stark JM, Mueller GA. Lung defense: intrinsic, innate, and adaptive. In: Chernick, Boat, Wilmott, Bush, eds.Kendig’s Disorders of the Respiratory Tract in Children. 8thed. (not yet published): Saunders Elsevier. 

Pascoe J, Shaikh U, Etzel RA, Forbis S. Health and nutrition as a foundation for success in school. In: School Readiness, Early Learning, and the Transition to Kindergarten. Towson, MD: Brookes Publishing Co; In press.

Pickoff AS. Developmental cardiac electrophysiology and the cardiac conduction system. In: Polin RA, Fox WW,eds.Fetal and Neonatal Physiology. 4thed. Philadelphia, PA: WB Saunders; In press.

Sizarov A, Moorman AFM, Pickoff AS. Development and functional maturation of the cardiac conduction system. In:  Moss and Adams’ Heart Disease in Infants, Children and Adolescents, Including Fetus and Young Adult. 8thed. LLW; In press.

Vidwan, NK,  Staat MA. Chlamydia. In: Rudolph AM, Rudolph CD, Siegel NJ, Lister G,Hostetter MK, eds. Rudolph’s Pediatrics Textbook.22nd ed.New York, NY: McGraw Hill; In press.

Abstracts and significant presentations

Patricia Abboud, MD, critical care medicine

  • ·Predictors of failure for high-flow high-humidity nasal cannula therapy in viral bronchiolitis.Paper presented at: Pediatric Academic Societies Annual Meeting;May 1-4, 2010; Vancouver, Canada.
  • ·Can a cup a day keep inflammatory bowel disease at bay? The green tea phenol,epigallocatechin-3-gallate, and colitis.Paper presented at: Society of Critical Care Medicine 39thEducational and Scientific Symposium; January 8-13, 2010; Miami Beach, FL.

Cecilia Amisola, MD, development pediatrics

  • Autism – complementary and alternative treatments.Presented at: Dayton Children’s; October 13, 2010; Dayton, OH.
  • Outcomes of prematurity. Presented at: Dayton Children’s; September 15, 2010; Dayton, OH. 

Farhat Ashai-Khan, MD, gastroenterology and nutrition

  • Schaefer MD, Langton CR, Markowitz J, Mack DR, Evans JS, Pfefferkorn MD, Griffiths AM, Otley AR, BousvarosA, Rosh JR, Keljo DJ, Carvalho RS, Kay MH, Olivia-Hemker M, Kappelman MD, Ashai-Khan F, et al.Post-intestinal resection management of Crohns disease. Paper presented at: Digestive Disease Week2010; May 1-5, 2010; New Orleans, LA

Paul Breyer, MD, medical director of endocrinology

  • Endocrine emergencies.Presented at: Acute Care Symposium, Dayton Children’s; August 25, 2010; Dayton, OH.
  • Return of rickets.Presented at: Grand Rounds, Dayton Children’s; December 8, 2010; Dayton, OH.
  • Diabetes mellitus in children and adolescents.Presented at: Dayton Public NurseConference, Dayton Children’s; August 20, 2010; Dayton, OH

Emmett Broxson, MD, medical director of hematology/oncology         

  • End-of-life discussions.Presented at: Wright State University Boonshoft School of Medicine; January 22, 2010; Dayton, OH.
  • Hematology emergencies.Presented at: Acute Care Symposium, Dayton Children’s; August 18, 2010; Dayton, OH.
  • Pain presentation series.Presented at: End-of-Life Nursing Education Consortium (ELNEC), Dayton Children’s; August 30, 2010; Dayton, OH.          

Ann Burke, MD, residency program director

  • Schumacher DJ, Lewis KO, Burke AE, et al. The pediatric milestones: initial evidence from cognitive interviewing for their use among senior residents. Poster presented at: Accreditation Council for Graduate Medical Education Annual Educational Conference;March 2011; Nashville, TN.
  • Schumacher DJ, Lewis KO, Burke AE, et al. The pediatric milestones: initial evidence from cognitive interviewing for their use among senior residents. Platform presentation at: Association of Pediatric Program Directors Annual Meeting;April 2011; Miami, FL.
  • McConnell E, Jaballas E, Stolfi A, Burke AE, et al. Enhancing resident knowledge of developmental pediatrics: tailored to residents’ development as clinicians. Presented at: SGEA Annual Meeting; April 15-17, 2010; Oklahoma City, OK.
  • Holmes AV, Burke AE, Stanton B, et al.Part-time is not for slackers: working hard to build flexible academic positions for yourself or for pediatricians in your program.Presented at: Pediatric Academic Societies Annual Meeting, Workshop;May 2, 2010; Vancouver, BC.
  • Gordon MB, Burke AE, Vinci RJ. Flexible training and work-life balance: the devil is in the details. Presented at: Association of Pediatric Program Directors (APPD) Annual Meeting;April 18, 2010; Chicago, IL.
  • Hicks PJ, Burke AE, Carraccio C. Assessment in medical education: what it is and what it is not. Presented at: Association of Pediatric Program Directors (APPD) Annual Meeting; April 18, 2010; Chicago, IL.
  • Blaschke GS, Johnson C, Burke AE, et al. Tools to save time: Bright Futures toolkit supports practice and quality improvement!Presented at: Association ofPediatric Program Directors (APPD) Annual Meeting;April 16, 2010; Chicago, IL.
  • Hobson-Rohrer W, Blankenburg R, Burke AE, et al. When knowledge isn’t enough: practical exercises for remediating professionalism, communication and clinical reasoning. Association of Pediatric Program Directors (APPD) Annual Meeting;April 16, 2010; Chicago, IL.
  • Fitzgerald M, Burke AE.Assessment in medical training: think like an idealist to be a better realist.Presented at: Cincinnati Medical Educator’s Faculty Development Conference; September 2010; Cincinnati, OH.
  • Burke A, Caputo G, Roberts K, et al.Leadership development plan for program directors. Presented at: APPD Fall Meeting; September 20, 2010; Reston, VA.

Merrilee Cox, MD, medical education

  • Passing the baton: hand-off communication. Presented at: Grand Rounds, Dayton Children’s; Dayton, OH.                      

Mukund Dole, MD, hematology/oncology

  • Sickle cell disease.Presented at: Grand Rounds, Reid Memorial, May 5, 2010; Richmond, IN.

Sam Dzodzomenyo, MD, medical director of pediatric sleep center

  • Overview of pediatric sleep disorders. Presented at: Family Practice Residency, Good Samaritan Hospital; March 2010; Dayton, OH
  • Current trends in pediatric sleep issues.Presented at: Indiana Society of Sleep Professionals; August 18, 2010; Indianapolis, IN.

Gregory Eberhart, MD, general pediatrics

  • Parents’ perspectives on their children’s health insurance: plight of the underinsured.Poster presented at: PBRN National Conference; June 2010; Washington, DC.
  • Geographic variation in parents’ perception of their communities’ social capital and associated factors.Presented at: PBRN National Conference; June 2010; Washington, DC.

Ashley Fernandes, MD, PhD, general pediatrics

  • Fostering active learning: using structured debate to teach ethics and professionalism to medical students. Presented at: The Generalists in Medical Education National Conference; November 2010; Washington, DC.
  • Toward a medical-student-centered ethics curriculum: ethical issues encountered in the first year. Poster presented at: American Society of Bioethics and Humanities NationalConference;October 2010; San Diego, CA.
  • Sexual abstinence counseling among residents and physicians in a Catholic pediatric residency program. Poster presented at: Catholic Medical Association National Conference;October 2010; Seattle, WA.
  • Child abuse: what EMS should know.Presented at: Ohio Association of Emergency MedicalServices State Conference;October 2010; Springfield, OH.

Shalini Forbis, MD, general pediatrics        

  • Forbis SG, Brigham EL, Stolfi A, Pascoe JM, et al. Rates of immunization and well-child care adherence in an underserved setting. Poster presented at: Pediatric Academic Societies Annual Meeting; May 2010; Vancouver, Canada.
  • Forbis SG, Brigham EL, Stolfi A, Spears W, Pascoe JM, et al.Healthcare provider knowledge and use ofrecommended health literacy techniques.Poster presented at:Pediatric Academic Societies Annual Meeting; May 2010; Vancouver, Canada.
  • Forbis SG, Goldenberg LE, Brigham E, Stolfi A, Mueller GA. The association between health literacy, ability to use written asthma plan and asthma control.Poster presented at:Pediatric Academic Societies Annual Meeting; May 2010; Vancouver, Canada.
  • Goldenberg LE, Forbis SG, Brigham E, Stolfi A, Mueller GA. Parental ability to correctly utilize written asthma management plans.Poster presented at:Pediatric Academic Societies Annual Meeting; May 2010; Vancouver, Canada.
  • Cull W, Federico S, Glusman M, Forbis S. When should children assume responsibility for managing their health? Platform presentation at: Pediatric Academic Societies Annual Meeting; May 2010; Vancouver, Canada.

Eileen Kasten, MD, medical director of developmental pediatrics         

  • DeWitt MB, Greenwell S. Diagnosis and assessment of autism spectrum disorders:  Standards for best practice.Presented at: Autism Society workshop, Wright State University; November 6, 2010; Dayton, OH.           

Gogi Kumar, MD, neurology

  • Movement disorders in children.Presented at: Grand Rounds, Dayton Children’s; Dayton, OH.

Daniel Lacey, MD, PhD, neurology

  • Chronic headaches in children.Presented at: International Pain Week 2010; September 2010; Las Vegas, NV.
  • Idiopathic chronic pain disorders in children and adolescents.Presented at: International Pain Week 2010; September 2010; Las Vegas, NV.

Sonia Michail, MD, gastroenterology and nutrition         

  • Michail S, Ahles E, Kenche H, Abernathy F, Turner D, Reo N.The gut microbiome and its metabolite profile in children with diarrhea-predominant irritable bowel syndrome. Platform presentation at: NASPGHAN 2010; Awarded best motility abstract.
  • Durbin M, Wine E, Turner D, Griffiths AM, Kenche H, Stolfi A, Michail S. The gut microbiome in children with severe ulcerative colitis. Platform presentation at: Digestive Disease Week 2010.
  • Michail S,Abernathy F, Kenche H, Stolfi A. VSL#3 use in a double-blind, placebo-controlled pilot trial in diarrhea-predominant irritable bowel syndrome. Poster presented at: Digestive Disease Week 2010.
  • Michail S,Kenche H. The fecal microbiome in children with diarrhea-predominant irritable bowel syndrome. Platform presentation at: Digestive Disease Week 2010.Rosh JR, Mohamed A, Dougherty K, Lerer T, Keljo DJ, Mack DR, Griffiths AM, Crandall W, Bousvaros A, Kay, Marsha H, Grossman AB, Pfefferkorn MD, Michail S, et al.Clinical effect and changing patterns of use of methotrexate in the treatment ofpediatric Crohn’s disease: amulti-center experience. Presented at: Digestive Disease Week2010.
  • Pfefferkorn MD, Langton CR, Mack, David R, Otley AR, LeLeiko NS, Stephens MC, Michail S,et al.NOD2 mutations and presenting clinical characteristics of Crohn’s disease (CD) in children. Presented at: Digestive Disease Week2010.
  • Hyams, JS, Lerer T, Mack DR, Bousvaros A, Griffiths AM, Rosh JR, Otley AR, Evans JS, Stephens M, Kay, Marsha H, Keljo DJ, Leleiko NS, Saeed S, Crandall W, Michail S, et al. Outcome following thiopurine use in children with ulcerative colitis: a prospective multicenter study. Presented at: Digestive Disease Week2010.
  • Mack DR, Markowitz J,Lerer T, Griffiths A, Evans J, Otley A, Bousvaros A, Pfefferkorn MD, Rosh J, Crandall W, MichailS, et al. Upper gastrointestinal involvement in pediatric Crohn’s disease: experience of a large multicenter inception cohort. Presented at: Digestive Disease Week 2010.

Marvin Miller, MD, director of medical genetics  

  • Miller ME, Hyman C, Ayoub D. Metabolic bone disease in young infants with multiple unexplained fractures:multifactorial in etiology and often confused for child abuse.Poster presented at: Gordon Research Conference on Biomineralization, Colby-Sawyer College; August 15-20, 2010; New London, NH.
  • Miller ME, Hyman C, Ayoub D.Metabolic bone disease in young infants with multiple unexplained fractures: multifactorial in etiology and often confused for child abuse.Poster presented at: Wright State University CentralResearch Forum; October 26,2010; Dayton, OH.
  • Ayoub D, Hyman C, Miller ME.Evidence of metabolic bone disease in young infants with multiple fractures misdiagnosed as child abuse. Poster presented at: American Society for Bone and Mineral Research; October 15-19, 2010;Toronto,Canada.
  • Ayoub D, Miller ME, Hyman C. The forgotten signs of healing rickets in early infantilehypovitaminosis D. Platform presentationat: Radiological Society of North America; December 3, 2010; Chicago, IL

Gary Mueller, MD, pulmonary medicine

  • Castile R, Mueller G, Long F, Flucke R, BakerB, CliffordB. Effects of nebulized recombinant human deoxyribonuclease (Dornase Alfa) in infants with cystic fibrosis evaluated using infant pulmonary function testing and high-resolution computerized tomographic imaging of the chest.Presented at: 23rd Annual North American Cystic Fibrosis Conference; October 15-17, 2009; Minneapolis, MN.
  • Also see Shalini Forbis, MD.

 Abiodun Omoloja, MD, nephrology

  • Bruner K, Chand D, Patel H, Stolfi A, Omoloja A. Pediatric nephrologists, chronic kidney disease and tobacco counseling: identifying practice patterns. Presented at: The 15th Congress of the International Pediatric Nephrology Association; 2010; New York, NY.
  • Omoloja A, Ferris M, Greenbaum L, et al.Urine cotinine, second hand smoking [SHS] exposure and adolescent chronic kidney disease [CKD].Presented at: The 15th Congress of the International Pediatric Nephrology Association; 2010; New York, NY. 

Gary Onady, MD, PhD, internal medicine/pediatrics       

  • From jazz to medicine: exploring improvisation in clinical practice, internal medicine. Presented at: Annual Meeting, American College of Physicians;April 2010;Toronto, Canada.
  • Using evidence-based medicine toward creating an evidence-based practice. Presented at: Bioethics Network of Ohio;May 2010; Columbus, OH.

John M. Pascoe, MD, general pediatrics

  • Lee M, McNicholas C, Pascoe JM.Mothers' persistent depressive symptoms and their preschool children’s math and literacy skills: a national study.Presented at: Pediatric Academic SocietiesAnnual Meeting; May 1, 2010; Vancouver, Canada. E-PAS20101380.7.
  • Spears W, Pascoe JM, McNicholas C, et al. Parents' perspectives on their children’s health insurance: plight of the underinsured.Presented at: Pediatric Academic Societies Annual Meeting; May 4, 2010; Vancouver, Canada. E-PAS20104402.150.
  • McNicholas C, Spears W, Specht S, Looman W, Pascoe JM. A new social capital scale: geographic stability compared to the mother’s personal support and depressive symptoms. Presented at: AHRQ Annual PBRN Meeting; June 16-18, 2010; Bethesda, MD.
  • Pascoe JM, Spears W, McNicholas C. Parents' perspectives on their children’s health insurance: plight of the underinsured. Platform presentationat: AAP National Conference and Exhibition;October 3, 2010; San Francisco, CA.
  • Pascoe JM, McNicholas C, Specht S, Spears W, Looman W. A new social capital scale: geographic stability compared to mothers' personalsupport and depressive symptoms. Presented at: 3rd Congress of the European Academy of Paediatric Societies; October 23-26, 2010; Copenhagen, Denmark.
  • Spears W, Pascoe JM, McNicholas C, et al. Parents' perspectives on their children’s health insurance: plight of the underinsured. Presented at: 3rd Congress of the European Academy of Paediatric Societies; October 23-26, 2010;Copenhagen, Denmark.
  • Also see Shalini Forbis, MD.

Ruthann Pfau, PhD, medical genetics

  • Genetic counseling: tales from the clinic.Presented at: Central State University Careers in Biology Seminar; November 5, 2010; Wilberforce, OH.
  • Genetics and bleeding disorders. Presented at: Tristate BleedingDisorder Foundation, 2010 Annual Meeting;November 6, 2010; Mason, OH.
  • Genetics and bleeding disorders. Presented at: FAOIO(Family Annual Meeting of Hemophiliacs in Ohio) 2010 Conference;August 7, 2010; Columbus, OH.

 Moira Pfeifer, MD, endocrinology

  • MedStudy Pediatric Endocrine Board Review.September 2010; Dallas, TX

Arthur S. Pickoff, MD, cardiology, professor and chair, department of pediatrics, Wright State University Boonshoft School of Medicine

  • MedStudy Pediatric Cardiology Board Review. September 2010; Dallas, TX 
  • Sudden death in the young athlete: update on new data, controversies and recommendations.Presented at: Grand Rounds, Kettering Medical Center; August 2010; Kettering, OH.
  • Unexpected sudden cardiac in children and adolescents.Presented at: Terry King Symposium, Children’s Hospital of New Orleans; September 2010; New Orleans, LA.

Marc Raslich, MD, general pediatrics         

  • Prognosis: Validity and results.Presented at: University of Cincinnati, Medical Education Conference; 2010; Cincinnati, OH.
  • Evidence-based medicine: current trends and effective teaching methods. Presented at: Wright State University,Scholarship of Teaching and Research in Medical Education, Faculty Development Series(with P. Hudges); October 2010;Dayton, OH.
  • Creating significant learning experiences in medical education.Presented at: Central Group on Education Affairs (with P. Hudges), Association of American Medical Colleges (AAMC); 2010; Chicago, IL.
  • Creating significant learning experiences in medical education: using integrated course design to promote active learning (with P.Hudges).Presented at: The Generalists in Medical Education 31st Annual Conference;November 2010; Washington, DC.
  • Integrated course design: opportunities to create significant learning experiences in medical education(with P. Hudges).Presented at: Ohio State University Office of Medical Education, 2010-11, Faculty Development Series; Columbus, OH.
  • Effectiveness of a central immunization registry in improving immunization rates in a residency training program clinic.Presented at: Dayton Area Graduate Medical Education Consortium Annual Resident Research Forum (with A. Humpert); April 2010; Dayton, OH.
  • Do med-peds graduates maintain dual board certification? Presented at: Medicine-Pediatrics Program Directors Association Annual Session (with J. G. Frohna, A. Friedland and M. Aronica); April 2010; Baltimore, MD.
  • Enhancing medical education: increasing significant learning experiences throughintegrated course design.Presented at: Medicine-Pediatrics Program Directors Association Annual Session (with P. Hudges and A. Lowes);April 2010; Baltimore, MD.               

Adrienne Stolfi, MS, biostatistician, Wright State University Boonshoft School of Medicine 

  • Rowin ME, Abboud P, Roth P, Stolfi A.Predictors of failure for high flow high humidity nasal cannula therapy in RSV+ bronchiolitis. Poster presented at: Pediatric Academic Societies Annual Meeting;May 1-4, 2010; Vancouver, Canada. E-PAS20103715.160.
  • Durbin M, Wine E, Turner D, Griffiths AM, Kenche H, Stolfi A, Michail S. The gut microbiome in children with severe ulcerative colitis [abstract]. Gastroenterology.2010;138(suppl 1):S-28.
  • Dunn L, McGeady L, Geary M, Pennick L, Johnson M, Stolfi A.Hemophilia treatment center social workers' involvement with local bleeding disorder chapters: preliminary results of a national survey. Poster presented at:National Hemophilia Foundation 62nd Annual Meeting; November 11-13, 2010; New Orleans, LA.
  • Geary M, Dunn L, McGeady L, Pennick L, Johnson M, Stolfi A. The role and qualifications of the HTC social worker: preliminary results of a national survey. Platform presentationat:National Hemophilia Foundation 62nd Annual Meeting; November 11-13, 2010; New Orleans, LA.
  • Geary M, Pennick L, Johnson M, McGeady L, Dunn L, Stolfi A.The demographics of hemophilia treatment center social workers: preliminary results of a national survey. Poster presented at:National Hemophilia Foundation 62nd Annual Meeting; November 11-13, 2010; New Orleans, LA.
  • Also see Ann Burke, MD; Shalini Forbis, MD; Sonia Michail, MD; and Abiodun Omoloja, MD.

Navjyot Vidwan, MD, infectious disease

  • Vidwan NK, Steinhoff M. Prevalence of chlamydia trachomatis infection from maternal transmission to the neonatein Vellore, India. Presented at: NIH Fogarty Meeting; February 2010; Bethesda, MD.
  • Vidwan NK, Steinhoff M. Prevalence of chlamydia trachomatis infection from maternal transmission to the neonate in Vellore, India. Poster presented at: Pediatric Academic Societies Annual Meeting; May 2010; Vancouver, Canada.

Amit Vohra, MD, critical care medicine

  • Diabetic ketoacidosis.Presented at: PICU nursing series, Dayton Children’s; September 28-30, 2010; Dayton, OH.

Research

Other research

Dayton Children’s Clinical Trials (DCCT)

  • Funding for Dayton Children’s as a Cystic Fibrosis (CF) Therapeutics DevelopmentCenter (TDC) was approved this past year by the Cystic Fibrosis Foundation Therapeutics, Inc. (CFFT). Dayton Children’s has been recognized in the past as a CF Therapeutics Development Center. In selecting these sites, the CFFT considers such factors as previous enrollment in clinical trials, size of patient population and the care center accreditation status. These grants expedite research and development of new therapies for patients afflicted with cystic fibrosis. The pulmonary department continued their hard work in conducting several CF trials.
  • DCCT accelerated initiation of three IV oseltamivir clinical trials after a request from the Department of Health and Human Services to respond to last year’s H1N1 influenza pandemic. These studies focused on participants who were unable to take oral oseltamivir and meet other protocol criteria. These studies are ongoing for this year as well.
  • Neurology participated in two migraine headache studies for children ranging in ages from 6 to 17 years of age using an oral study medication approved by the FDA for adults but not yet for this age group. A third migraine trial is now underway for teens 12 to 17 years of age using a nasal spray study medication already approved by the FDA for adult use only.
  • DCCT reviewed numerous trials for study design, safety and scientific merit. Trials included, but were not limited to:
    • An oral study medication for bacterial skin infection
    • An oral study medication for attention-deficit/hyperactivity disorder (ADHD) associated insomnia
    • IV acetaminophen for acute pain
    • An investigational drug for severe sepsis.
  • Participation in some of these trials is still being considered.

Nursing and other staff research

Lucinda Brown, RN, nursing administration

  • Mock code: staff knowledge retention.
  • The effectiveness of distraction to decrease distress and improve coping.
  • Pediatric inpatient falls study.
  • Effect of parent education and engagement related to the initiation of a pediatric response team call.

Sandy Hibner, RN, hematology/oncology

  • High-fidelity human patient simulators (HPS) and telehealth: a pilot study in teaching for bleeding disorder education.Grant funded by Southwest Ohio Hemophilia Foundation from Baxter’s Facts First Program. 

Charlotte Lemming, social work

  • Prevalence and impact of depression and anxiety on CF patients and their caregivers. Sponsor: The CF Foundation.

Leah Sabato, RD, dietetics and nutrition

  • Prevalence of metabolic abnormalities in children with varying degrees of obesity.

Lisa Schwing, RN, Soin Pediatric Trauma and Emergency Center

  • Evaluation of pediatric trauma triage criteria for the highest trauma activation.

Stephanie Smith, RN, neurosurgery

  • A descriptive study of parenting styles, parental feeding behaviors and BMI percentile in school-age children and adolescents. Sponsor: Sigma Theta Tau International, Zeta Phi Chapter.

 

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