|Alternate:||CSF Lactic Acid; CSF Lactate|
|Available:||Daily, 24 hours|
|Volume:||0.5 mL spinal fluid|
|Container:||Sterile spinal fluid collection tube|
|Temperature:||Specimen must be PLACED ON ICE and delivered to lab within 30 minutes after collection.|
|Rejection:||In transport longer than 30 minutes, bloody tap, specimen not on ice.|
|Normal:||0.6-2.2 mmol/L. Lactate in CSF normally parallels blood levels. With biochemical alterations in the CNS, CSF lactate values change independently of blood values.|
|Uses:||Increased CSF levels are noted in cerebrovascular accidents, intracranial hemorrhage, bacterial meningitis, epilepsy, and other CNS disorders. Aseptic/viral meningitis lactate levels are usually not elevated and therefore used to discriminate between viral and bacterial meningitis, but the clinical utility has been questioned.|
|Limitations:||The effects of hemolysis and xanthochromia in CSF have not been evaluated.|
|Method:||Enzymatic two filter endpoint (NAD/NADH)|
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