|Includes:||Random, Peak, or Trough Theophylline|
|SQ Code:||THEO (RANDOM), THEP (PEAK), THET (TROUGH)|
|Available:||Daily, 24 hours|
|Turnaround:||Routine: 3 hours, STAT: 30 minutes|
|Container:||3 mL green top tube or green microtainer (sodium heparin)|
|Temperature:||Deliver to lab within 30 minutes.|
|Normal:||10-20 µgrams/mL |
Toxic: greater than 20 µgrams/mL
Critical: greater than 20 µgrams/mL
|Uses:||Monitor therapeutic drug level; Evaluate theophylline toxicity Time to collect: Trough: 30 minutes prior to next dose. Peak: One hour after oral dose; 30 minutes after IV infusion|
|Limitations:||A theophylline metabolite, 1,3-dimethyluric acid may cause falsely elevated results in uremic patients. A minor metabolite is caffeine. In the premature neonate, approximately 50% of theophylline is excreted unchanged in the urine and the remaining 50% undergoes metabolism to caffeine and 1,3-dimethyluric acid.|
|Method:||PETINIA (Particle enhanced turbidimetric inhibition immunoassay)|
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