Lab Test : Theophylline, Blood: Random, Peak, or Trough

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Alternate:Aminophylline
Includes:Random, Peak, or Trough Theophylline
Department:Chemistry
Phone:(937) 641-3428
SQ Code:THEO (RANDOM), THEP (PEAK), THET (TROUGH)
Available:Daily, 24 hours
Turnaround:Routine: 3 hours, STAT: 30 minutes
Specimen:Blood
Volume:0.2 mL
Container:3 mL green top tube or green microtainer (sodium heparin)
Temperature:Deliver to lab within 30 minutes.
Rejection:N/A
Normal:10-20 µgrams/mL
Toxic: greater than 20 µgrams/mL
Critical: greater than 20 µgrams/mL
Uses:Monitor therapeutic drug level; Evaluate theophylline toxicity Time to collect: Trough: 30 minutes prior to next dose. Peak: One hour after oral dose; 30 minutes after IV infusion
Limitations:A theophylline metabolite, 1,3-dimethyluric acid may cause falsely elevated results in uremic patients. A minor metabolite is caffeine. In the premature neonate, approximately 50% of theophylline is excreted unchanged in the urine and the remaining 50% undergoes metabolism to caffeine and 1,3-dimethyluric acid.
Method:PETINIA (Particle enhanced turbidimetric inhibition immunoassay)
 

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