Lab Test : Osmotic Fragility

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Alternate:RBC Fragility; Incubated Osmotic Fragility; Red Cell Fragility
Includes:N/A
Department:Hematology
Phone:(937) 641-3430
SQ Code:OSF
Available:Performed Sun-Thur, first shift only. Must be scheduled.
Turnaround:48 hours
Specimen:Blood
Volume:2 mL
Container:Green top tube
Temperature:Test must be performed on a fresh sample.
Rejection:Hemolysis, clotted tube, or dilution with IV fluid.
Normal:Results are depicted on a graph and submitted to the hematologists for interpretation.
Uses:Evaluation of hemolytic anemia especially for hereditary spherocytes. Resistance to osmotic lysis is characteristic of iron deficiency, thalessemia, and other hemoglobinopathies, especially Hemoglobin C disease.
Limitations:Any severe anemia including iron deficiency will give an abnormal curve. Test measures presence of spherocytes and spheroidal cells. Test is not specific for hereditary spherocytosis. Significant degree of spherocytosis from any cause will cause an abnormally increased fragility.
Method:Spectrophotometer
 

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